![]() ![]() OBTENCIÓN Y ANÁLISIS DE LOS DATOS: Dos autores de la revisión, de forma independiente, evaluaron los estudios para su inclusión y realizaron la extracción de los datos, la evaluación del riesgo de sesgo y la evaluación GRADE. CRITERIOS DE SELECCIÓN: Se incluyeron los estudios observacionales de cohortes y de casos y controles longitudinales prospectivos y retrospectivos con un seguimiento mínimo de un año, que examinaron la asociación entre una escala de medición de la carga anticolinérgica y el futuro deterioro cognitivo o demencia en adultos mayores sin deterioro cognitivo. MÉTODOS DE BÚSQUEDA: Se realizaron búsquedas en las siguientes bases de datos desde su creación hasta el 24 de marzo de 2021: MEDLINE (OvidSP), Embase (OvidSP), PsycINFO (OvidSP), CINAHL (EBSCOhost) e ISI Web of Science Core Collection (ISI Web of Science). Existen varias escalas para medir la carga anticolinérgica, pero la concordancia entre ellas suele ser mala.Įvaluar si la carga anticolinérgica, definida a nivel de cada escala individual, es un factor pronóstico de un futuro deterioro cognitivo o demencia en adultos mayores sin deterioro cognitivo. Es posible que una alta carga anticolinérgica sea un factor de riesgo para la aparición de un deterioro cognitivo o la demencia. El efecto anticolinérgico acumulado de todos los fármacos que toma una persona se denomina "carga anticolinérgica" por su potencial para causar efectos adversos. There is low-certainty evidence that older adults without cognitive impairment who take medications with anticholinergic effects may be at increased risk of cognitive decline or dementia.Ī los adultos mayores se les prescriben con frecuencia fármacos con propiedades anticolinérgicas. Exploratory analysis combining adjusted ORs across available scales supported these results (OR 2.16, 95% CI 1.38 to 3.38), and there was evidence of variability in risk based on severity of anticholinergic burden (ACB scale 1: OR 2.18, 95% CI 1.11 to 4.29 ACB scale 2: OR 2.71, 95% CI 2.01 to 3.56 ACB scale 3: OR 3.27, 95% CI 1.41 to 7.61) however, overall GRADE evaluation of certainty of the evidence was low. Unadjusted ORs suggested an increased risk for cognitive decline or dementia in older adults with an anticholinergic burden (OR 1.47, 95% CI 1.09 to 1.96) and adjusted ORs similarly suggested an increased risk for anticholinergic burden, defined according to the ACB scale (OR 2.63, 95% CI 1.09 to 6.29). The Anticholinergic Cognitive Burden scale (ACB scale) was the only scale with sufficient data for 'scale-based' meta-analysis. Eight studies (320,906 participants) provided suitable data for meta-analysis. Twenty studies were conducted in the community care setting, two in primary care clinics, and three in secondary care settings. We identified 25 studies that met our inclusion criteria (968,428 older adults). ![]() We examined variability based on severity of anticholinergic burden. We initially established adjusted and unadjusted pooled rates for each available anticholinergic scale then, as an exploratory analysis, established pooled rates on the prespecified association across scales. We intended to pool each metric separately however, only OR-based data were suitable for pooling via a random-effects meta-analysis. ![]() We extracted odds ratios (OR) and hazard ratios, with 95% confidence intervals (CI), and linear data on the association between anticholinergic burden and cognitive decline or dementia. Two review authors independently assessed studies for inclusion, and undertook data extraction, assessment of risk of bias, and GRADE assessment. We included prospective and retrospective longitudinal cohort and case-control observational studies with a minimum of one year' follow-up that examined the association between an anticholinergic burden measurement scale and future cognitive decline or dementia in cognitively unimpaired older adults. We searched the following databases from inception to 24 March 2021: MEDLINE (OvidSP), Embase (OvidSP), PsycINFO (OvidSP), CINAHL (EBSCOhost), and ISI Web of Science Core Collection (ISI Web of Science). To assess whether anticholinergic burden, as defined at the level of each individual scale, is a prognostic factor for future cognitive decline or dementia in cognitively unimpaired older adults. There are various scales available to measure anticholinergic burden but agreement between them is often poor. It is possible that high anticholinergic burden may be a risk factor for development of cognitive decline or dementia. The cumulative anticholinergic effect of all the medications a person takes is referred to as the 'anticholinergic burden' because of its potential to cause adverse effects. Medications with anticholinergic properties are commonly prescribed to older adults. ![]()
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![]() Weapons are the party’s main means of zombie-slaying in Death Road to Canada. It is a Indie Action-RPG with randomization elements within the games atmosphere that allows it to orchestrate events and obstacles for players in the game. Each day, the player must also deal with a variety of different Events, which may either help them or hurt them depending on which choices they make. During the two-week journey, the player must fight zombies, go Looting, and manage their Supplies in order to survive. The ultimate goal of the game is to reach Canada, which is apparently safe from zombies. Through text the player is presented with multiple choices that they benefit from or are harmed by the decisions are affected by each character’s backgrounds and moods In Death Road to Canada, the player controls a group of up to 4 characters as they attempt to drive across the zombie-infested United States of America. Death Road has interactive fiction events in between times spent in locations. Occasionally, the player will encounter “siege” events, where they need to survive a growing zombie horde for a set amount of time. The player can use different types of weapons from melee to ranged. Every run, the player stops at locations, trying to find supplies like medkits, weapons, gasoline, and food to survive. Each character you meet can join your party (up to four characters), and all of them have varying mood levels, different skills, and backgrounds. ![]() Death Road to Canada takes place over two in-game weeks as the party tries to make it to the border. The game starts with two survivors going on a road trip, hoping to escape the zombie apocalypse in America, and escape to Canada. ![]() However, they are based somewhat from the options you are provided with. ![]() Stories and settings for individual segments of the game are randomly generated. Tell people to “Cool it.” 4 player local same screen co-op where you control up to 4 characters! he game is a roguelike in which the player tries to get to Canada in order to escape the zombie-infested United States, One of the best features of the game is the way in which it is randomly generated. Most family friendly zombie apocalypse game on the market! Any gore explosion is in a cute style. Get your characters strong enough to throw large sofas. Get different options and results based on the traits of your party members. Death Road to Canada Free Download Repacklab ![]() ![]() ![]() However, his book attracted no attention until long after his death. He also proposed a universal time to be used in astronomy and telegraphy. He proposed 24 hourly time zones, which he called "longitudinal days", the first centred on the meridian of Rome. Italian mathematician Quirico Filopanti introduced the idea of a worldwide system of time zones in his book Miranda!, published in 1858. For the global time standard, see Universal Time. Congress in the Standard Time Act of March 19, 1918. The confusion of times came to an end when standard time zones were formally adopted by the U.S. A notable exception was Detroit (located about halfway between the meridians of Eastern and Central time), which kept local time until 1900, then tried Central Standard Time, local mean time, and Eastern Standard Time (EST) before a May 1915 ordinance settled on EST and was ratified by popular vote in August 1916. Within a year 85% of all cities with populations over 10,000 (about 200 cities) were using standard time. The North American zones were named Intercolonial, Eastern, Central, Mountain, and Pacific. It was inaugurated on Sunday, November 18, 1883, also called "The Day of Two Noons", when each railroad station clock was reset as standard-time noon was reached within each time zone. For example, the border between its Eastern and Central time zones ran through Detroit, Buffalo, Pittsburgh, Atlanta, and Charleston. The borders of its time zones ran through railroad stations, often in major cities. Allen, the editor of the Traveler's Official Railway Guide. and Canadian railroads implemented a version proposed by William F. Dowd's system was never accepted by North American railroads. In 1870 he proposed four ideal time zones having north–south borders, the first centered on Washington, D.C., but by 1872 the first was centered on meridian 75° west of Greenwich, with natural borders such as sections of the Appalachian Mountains. Dowd proposed a system of hourly standard time zones for North American railroads around 1863, although he published nothing on the matter at that time and did not consult railroad officials until 1869. 1913 time zone map of the United States, showing boundaries very different from todayĬharles F. Some junctions served by several railroads had a clock for each railroad, each showing a different time. Each railroad used its own standard time, usually based on the local time of its headquarters or most important terminus, and the railroad's train schedules were published using its own time. Timekeeping on North American railroads in the 19th century was complex. ![]() This standard was known as New Zealand Mean Time. It was based on longitude 172☃0′ east of Greenwich, that is 11 hours 30 minutes ahead of GMT. On November 2, 1868, the then British Colony of New Zealand officially adopted a standard time to be observed throughout the colony. Some British clocks from this period have two minute hands, one for the local time and one for GMT. By 1855, 98% of Great Britain's public clocks were using GMT, but it was not made the island's legal time until August 2, 1880. This practice was soon followed by other railway companies in Great Britain and became known as Railway Time.Īround August 23, 1852, time signals were first transmitted by telegraph from the Royal Observatory. In November 1840, the Great Western Railway started using GMT kept by portable chronometers. In the 19th century, as transportation and telecommunications improved, it became increasingly inconvenient for each location to observe its own solar time. Some locations use it year-round.Main article: Railway time Plaque commemorating the Railway General Time Convention of 1883 in North America The control panel of the Time Zone Clock in front of Coventry Transport Museum In North America, it is observed in the Mountain Time Zone during standard time, and in the Pacific Time Zone during the other eight months (see Daylight saving time). UTC−07:00 is an identifier for a time offset from UTC of −07:00. UTC−07:00: blue (January), orange (July), yellow (year-round), light blue (sea areas) Time in Nunavut ![]() ![]() Fixed an issue where glass panes in the environment did not have proper collision.Fixed an issue where it would become difficult to pick up items from a close distance.Fixed an issue where the shooting animation would become corrupted when the player stopped aiming down the sites.Fixed an issue where the player could scroll outside of the map’s borders in the menu.Fixed an issue where the Airdrop Supply Marker would disappear when the player moves out of range.Fixed an issue where the map in the map menu would load more slowly for clients in an online session.You may enable or disable this setting within the Controls menu. ![]() ![]()
![]() ![]() Some people just have “it,” and so do some cars. Even so, its more compact dimensions and quality build, along with its interesting styling, gave it an undeniable presence. The “Squarebird” had nice proportions, for sure, even if it arguably paled stylistically in comparison to the next two generations. Therefore, one must assume that the Thunderbird’s styling had much to do with its success. Ford, recognizing its own success, even copied the T-Bird’s roofline for certain Galaxie and Falcon models, creating the “Thunderbird look,” a move that could have diluted the image, but probably helped overall sales instead. It looked special, and nobody else had anything like it.įord beat GM to the punch surprisingly often in certain market segments, the T-Bird, Mustang, and LTD being examples of “better ideas” that sent GM scrambling for their drawing boards. When Ford introduced the four-seater ‘Bird for 1958, sales immediately exploded because Ford had made its dream car practical. ![]() It was unlike any other Ford or Mercury, and it was luxurious and attractive. Most likely, its popularity stemmed from its attainable distinctiveness. What accounted for this cachet? Why was the T-Bird such a special thing? (first posted ) Have you ever considered how odd it is that Ford, that manufacturer of solid, reliable, conservative transportation, produced a true competitor to Cadillac and Lincoln? The T-Bird, at least until the mid-1960s, was a status symbol for the rich and moderately well-off, a thing of beauty that really had a market all to itself until the Riviera came along in 1963 and even then, the T-Bird sold in greater numbers. ![]() ![]() ![]() at JBB's you can find all your beads and findings needs, from one reliable manufacturer. JBB Findings is a major manufacturer of high quality beads and findings in Sterling Silver, Anti Tarnish Brass, Copper and Pewter. at JBBs you can find all your beads and findings needs, from one reliable manufacturer. ![]() Shop now using our primary menu links at the top of the page for some of the most popular sections shown in the visual buttons above. W elcome to JBB Findings new web site and catalog. W elcome to JBB Findings new web site and catalog. This is due to surface area limitations and the fact that stamping individual findings would detract from their appearance once combined.Īt Halstead, we offer thousands of sterling silver jewelry parts for sale online at wholesale prices. Individual findings and parts are not required to be stamped. However, even high-end designers sometimes favor the metal for its unique color and working properties.įinished jewelry items created using sterling silver components should bear a. ![]() Gold Filled 6mm Solder Flush End Cap Item Weight Approximately 20 Grams Per 100 Pieces (Sold by Piece) 2.80. Favored by many middle market designers because it is a high quality, lustrous material that is also affordable for most people. 14KW 9.86X8mm Width Thick Diamond Block Initial O Item Weight Approximately 73.89 Grams Per 100 Pieces (Sold By Piece) 52.53. Sterling silver is used in a wide range of jewelry styles and sold at various price points. FREE delivery Thu, Jul 27 on 25 of items shipped by Amazon. Shop our huge array of earring findings including ear wires, leverbacks, posts, threaders, jackets and hoop earrings for pierced ears. 24 Pairs Magnetic Necklace Bracelet Clasps Magnet Converter Jewelry Clasps Extenders Locking Clasps for Bracelet Necklace Making (Silver) 174. ![]() ![]() Lego Brawls is a kid-friendly brawler that lets players compete in four-on-four multiplayer battles using all sorts of realistic and comedic Lego minifigure fighters. As you play, the more volunteers you gather, the more luck your movement will have, so you must try to convince the islanders to join the cause. With the help of her bird-nerd grandfather and Ines, Alba starts a grassroots campaign to clean up the island. But once she starts exploring, she realizes that there's a litter problem putting local animals at risk. ![]() In Alba, the titular character travels to a Mediterranean island to spend the summer with her grandparents. Painty Mob features dozens of playable characters to unlock, so kids can have tons of fun for quite a while with this one. While your intentions are good, it turns out that people don’t like being splattered with paint, so every citizen you hit becomes part of an angry mob that will endlessly chase you until you either complete a stage or get hit by someone in the mob, which ends the game. This colorful “endless survival” game challenges players to spread joy through the world by splattering paint on unsuspecting citizens to earn points. ![]() SpongeBob Patty Pursuit features lots of replayability, since some levels contain areas that are only accessible when using specific friends. Each level is full of coins and hidden spatulas that you can collect, and as you rescue SpongeBob’s pals, you can take them into future levels with you and use their special abilities as you play. In each level, SpongeBob runs across the screen automatically, and you can swipe on the screen to make him jump, defeat an enemy (Plankton’s cousins), and more. ![]() You’ll need to help SpongeBob rescue his friends and stop Plankton from getting away with the recipe. In this side-scrolling platformer inspired by the hit television series, Plankton has destroyed the Krusty Krab, stolen the Krabby Patty formula, and taken SpongeBob’s friends captive. You'll race on teams with Sonic, Tails and Knuckles at the start, and you can change your team to other characters like Shadow, Amy and others as you level up. The game is fun and the controls aren't hard to pick up. Maneuver your car to grab as many rings as possible, avoid traps and win. There's a good chance you know who the speedy little hedgehog is, even if you've never played the games. This Classic+ version for Apple Arcade features fun fruit-slicing gameplay, but without in-game purchases. In Fruit Ninja, fruit and bombs appear on the screen for a short period of time, and you’re challenged to swipe your finger across the pieces of fruit to cut them while avoiding the bombs.įruit Ninja is even more fun now you can compete with your friends online to find out once and for all who has the best fruit-cutting skills. However, at this time, children may not be able to play in multiplayer games. As an Apple Arcade title, Wonderbox: The Adventure Maker is playable on iPhone, iPad, Apple TV, and Mac, and supports game controllers.Ĭut the Rope is a physics-based puzzle game on Apple Arcade that challenges players to feed candy to a friendly (and adorable) monster named Om Nom (as well as his friends) by cutting ropes and manipulating other objects in each stage.Ĭut the Rope Remastered challenges players to think ahead before making each move, but there’s no penalty for making a mistake - players can simply reset the stage and try again until they succeed. Your mission is to deliver sweet treats to Om Nom, the little green monster with a candy addiction.įruit Ninja Classis is a simple yet addictive game for kids. ![]() Wonderbox allows players to explore adventures with other players through online multiplayer. They can also create their own worlds and share them with the game’s community. Players can complete adventures created by the developer, as well as those created by other players. Wonderbox: The Adventure Maker is an adventure game exclusively for Apple Arcade. Crayola Create and Play+ is a colorful educational app that offers lots of art and learning activities for kids, as well as arcade games. Crayola Create and Play is loaded with fun features like coloring pages, tending to in-game creatures and plants, learning and arcade-style games, puzzles, and more.Ĭrayola Create and Play is fully unlocked with an Apple Arcade subscription. Crayola Create and Play also has a parents hub that explains how the app works, what activities are available to explore, settings, an FAQ for any extra questions, and more. ![]() ![]() ![]() Using Technology Better uses personally identifiable information for essential communications, such as If we have trouble processing an order, we will use this information to contact you. We use this information for billing purposes and to fill your orders. You may be required to provide contact information such as:įinancial information (such as credit card number, expiration date, name on card, card billing address). If you purchase a product or service from us, we may request certain personally identifiable information from you. If your personally identifiable information changes, or if you no longer desire our service, you may correct, update, delete or deactivate it by emailing us at. 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Using Technology Better Privacy Commitment ![]() Here is the easiest way to cite resources such the author name and websites: When they do, the image will be automatically cited (see the number 1 in the image below) and the link in the footer at the bottom of the Google Doc. Your students then just simply drag and drop the image into their Google Doc. Your students can then type in the subject and click the little g next to their search term and choose images.Ī number of images will appear. If your students are using Chrome as their browser to access their Google Docs, they can click on Tools then Research.įrom there a section will open up on the right of the page. Competencies for students :: cite resources Here is the easiest way for your students to cite images: In Australia, the ACARA ICT General Capabilities (Australian National Curriculum for our overseas readers) suggest that a student should credit other peoples images by the end of year 4 and cite all sources including authors names and websites by the end of year 6. A great 21st Century Learning Skill (I would ague the century is irrelevant), is to be able to cite other sources correctly. ![]() ![]() ![]() "It's just that no two people are alike," he said.Minutes after my tattoo artist completed my floral wrist design at Ephemeral Tattoo Tattoos - permanent or not - fade differently on different bodies, depending on a myriad of factors including age, placement, skin-care routine and contact with the sun. Roy Grekin, director of the Dermatologic Surgery and Laser Center at UC San Francisco, told the San Francisco Chronicle that he's not surprised Ephemeral customers experienced dramatically different fade times. eventually shrink over time," breaking down into "small enough sizes that our immune system can remove them," co-founder Brennal Pierre, a chemical engineer, explained in a Reddit post.ĭr. Regular tattoos involve injecting ink particles that are too large to be washed off with water or destroyed by the body's immune system.Įphemeral created "an ink particle that would. He said the majority of customers are satisfied with the results. ![]() Since then, he says Ephemeral has learned that "some customers will just take the initial tag line at face value," and the company is now "more deliberate about how we drive home a message about variability." Jeff Liu, the chief executive of Ephemeral, told the New York Times that its early marketing materials promising the tattoos would be "gone in a year" was "oversimplifying" the process. Laura Neilson, 41, of New York City, had the word 'reveal' tattooed on her wrist in April 2021. ![]() "It looks like a 70-year-old tattoo," she said. More than a year later, it's still there - albeit patchy and faded. "This seemed like a good way to sort of test my reaction to having something on my skin and test my reaction to the application process." So I've always been interested in tattoos, but I've always been scared of the longevity, the pain, etc.," she said. I'm somebody who is, like, a relatively anxious person. The company's website boasted at the time that it offered tattoos that would be "gone in a year." That copy has since been updated to: "Tattoos that last at least a year. When Edmonds got an Irish Claddagh ring tattooed on her arm at an Ephemeral shop in August 2021, she didn't expect it would still be there 18 months later. The letter also promised "your money back" if a tattoo lasts for more than three years. The company's updated guarantee promises that 70 per cent of tattoos will fade in under two years, and they will all disappear eventually. "Since our public launch in 2021, our team of chemical engineers has made a number of improvements to Ephemeral ink to implement your requests and feedback. These improvements in tattoo vibrancy, placement, design and healing have led to more options, meaning more variability in fade durations by individuals." "Ephemeral ink was designed to fade in about nine to 15 months, as determined by both pre-launch case and clinical studies," it reads. When asked for comment, Ephemeral directed CBC to a letter on its website by CEO Jeff Liu. "I wish I had more information before I'd gotten it."Įdmonds is one of several Ephemeral customers who say their tattoos have lasted longer than they'd expected, some as much as 22 months and counting. "I do regret it," Barbara Edmonds, whose tattoo is still visible after 18 months, told As It Happens host Nil Köksal. Their motto at the time was: "Regret nothing." ![]() It now operates studios in New York City, San Francisco, Houston, Atlanta, Miami and Washington, D.C As It Happens 6:18 Tattoos that will be 'gone in a year'? Not so much, say regretful customersĪ tattoo company that markets its ink as "made to fade" has come under fire from customers who say the tattoos are not as temporary as they'd hoped.Įphemeral, a New York-based company founded by two chemical engineers, launched to the public in 2021 to much fanfare on the premise of real tattoos that are made to fade within nine to 15 months. ![]() ![]() ![]() So for now, let’s enjoy the funniest and most relatable memes to come out of last night’s new episode. Is it game-over for Tayshia and Brendan this season of The Bachelorette? It’s definitely too early to tell. ![]() However, the source also adds that Robertson getting the rose didn’t really guarantee the San Diego native’s place on the show. Tayshia Adams may have met her match on The Bachelorette. As it turns out, Brendan has also been married and divorced, and their date ended with a romantic fireworks show. As per Steve, Spencer is the one who gets the coveted first impression rose from Tayshia. Spencer got the first impression rose from Tayshia in week 5. This week on 'The Bachelorette,' Tayshia had her 'grown-ass man' group date and party, a cocktail party and Rose Ceremony, and a wrestling group date with a night portion. Tayshia chose this lucky contestant for her one-on-one date, and the two really hit it off. Tayshia Adams wanted to separate the men from the boys on Tuesday’s episode of 'The Bachelorette,' and, unsurprisingly, she did it in perfect fashion. She gave her first impression rose to newcomer Spencer, and sadly Jason decided he would have to leave because he still had feelings for Clare.īut arguably the most exciting part of the episode was her time spent with Brendan. To catch you up, last night’s episode featured Tayshia’s first introduction with the guys, an unnecessary interview with Chris Harrison, Clare Crawley, and Dale Moss, and back to Tayshia on her group dates. As you’d expect, it appears the men are also totally into the show’s leading lady, even if we did lose one contestant last night. The season featured 29-year-old Tayshia Adams, a former phlebotomist, and 39-year-old. Along with Tayshia, many viewers felt bad for Spencer. Jen was the first Bachelorette to hand out a first impression rose, and she gave it to a man named Keith. The 16th season of The Bachelorette premiered on October 13, 2020. Thats why when Spencer got in a scuffle with Riley Christian during the pool basketball game, it resulted in the former bleeding from his mouth. AND subscribe to this podcast by hitting the plus or follow button so you don't miss an episode.Is anyone not smiling after Tayshia Adams‘ first official episode as the Bachelorette? Seriously, she is was like a much-needed breath of fresh air when she came to the resort. But after getting Tayshias first impression rose, the rest of the suitors somewhat felt intimidated or jealous. ![]() Join the evolve Facebook community > /groups/evolveautism where I do an exclusive Q+A about the episode topic each week. (SPOILER ALERT: Spencer received Tayshias first impression rose.) So who is this handsome 30-year old Heres what you need to know. ***disclaimer: not clinical advice, for educational purposes only*** from providing psychoeducation about autism and neurodiversity to talking about your personal growth, well-being, and evolution as a parent, we dive into it all. each week we will discuss topics that directly impact your life. In addition to the 16 men remaining from Clare Crawley's run as the. Reality Steve spilled all the tea on the last rose ceremony. Getty/Phillip Faraone/FilmMagic Reports of who Adams gave her first impression. NovemABC/Craig Sjodin There's a new Bachelorette in town and she brought four new suitors along with her. Katie was so decisive handing out roses and sending villains home that filming finished one week early with a non-traditional ending. Tayshia came in next and also had the opportunity to give out a first impression rose. Those that follow all the spoilers and rumors know how that situation has reportedly turned out. Ever since she received America’s First Impression Rose at The Bachelorette season 19 finale, fans have wanted to know more about Brianna from The Bachelor 2023 and where she is now after Zach. i have supported 100s of autistic children and their families and have been in the autism field for over a decade. Tayshia Adams attends ABC's TCA Summer Press Tour Carpet Event on August 05, 2019, in West Hollywood, California. Clare reportedly gave her first impression rose to Dale Moss. Tay, a licensed child psychologist and parental mindset coach specializing in autism. tay | real conversations designed for autism parentsĪ podcast that was made for you as a parent of an autistic child (or a parent with concerns)! a place you can go for reliable and reputable information. ![]() |
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